DSG3 and head and neck squamous cell carcinoma: One revelation was the downregulation of an apoptosis candidate gene, sFRP, and a tumorigenesis suppressor gene, DSG3, in SCCHN that are also found by other investigators in other tumour tissues (Finch et al, 1997; Zhou et al, 1998), demonstrating that different tumours may share a common molecular mechanism in tumorigenesis.