AKT1 and plasma cell myeloma: The PI3K/Akt pathway is said to be an antiapoptotic pathway in myeloma (Tu et al, 2000) although numerous groups have found that PI3K plays a key role in migration and gradient-sensing in other cell types (Gerszten et al, 2001; Comer and Parent, 2002; Curnock et al, 2002; Stephens et al, 2002; Weiner, 2002).