Insulin-like growth factor-1 also stimulates the proliferation and survival of MM cells (Freund et al, 1994; Georgii-Hemming et al, 1996; Ferlin et al, 2000; Qiang et al, 2002) and has been described to increase the expression of VEGF and thus angiogenesis in colon cancer cells (Fukuda et al, 2002). Here, VEGFA is linked to malignant colon neoplasm.