IGF1 and malignant colon neoplasm: Insulin-like growth factor-1 also stimulates the proliferation and survival of MM cells (Freund et al, 1994; Georgii-Hemming et al, 1996; Ferlin et al, 2000; Qiang et al, 2002) and has been described to increase the expression of VEGF and thus angiogenesis in colon cancer cells (Fukuda et al, 2002).