PDGFRB and malignant glioma: In addition, treatment with the truncated PDGFR or the PDGFR tyrosine kinase inhibitors such as STI-1571 or CT52923 inhibited PDGFR signaling, and the in vitro and in vivo growth of malignant gliomas (Strawn et al, 1994; Kilic et al, 2000; Lokker et al, 2002).