High ACE mRNA expression was found in tumour vessels (Figure 2Q, R), confirming our previous observation of a high expression of ACE protein in glioblastoma vasculature by immunohistochemistry (Juillerat-Jeanneret et al, 2000), but only at a very low level in the vessels of nontumoral tissue (Figure 2N, O). The gene discussed is ACE; the disease is glioblastoma.