We have previously shown that endothelin receptor antagonists sensitise glioblastoma cells to Fas-L-induced apoptosis involving the ERK pathway and the regulation of anti/proapoptotic molecules (Egidy et al, 2000), raising the possibility of a comparable role for renin/renin-receptor functions, since we show here that RO0663525 can induce apoptosis in human glioblastoma cells. Here, REN is linked to glioblastoma.