Support for this hypothesis is provided by experiments where Colon 38 tumours were implanted in TNF−/− and TNFR−/− knockout mice, where the antitumour effects following administration of the same dose of DMXAA are substantially reduced (Ching et al, 1999; Zhao et al, 2002). The gene discussed is TNFRSF1A; the disease is neoplasm.