However, mutation analysis of APC and β-catenin in GEJ adenocarcinomas revealed mutations in only less than 7 and 3% of cases respectively (Powell et al, 1994; Gonzalez et al, 1997; Bian et al, 2000; Choi et al, 2000). This evidence concerns the gene APC and gastroesophageal junction adenocarcinoma.