To date only APC and β-catenin mutation analysis in GEJ adenocarcinomas has been performed and only few mutations were found (Powell et al, 1994; Gonzalez et al, 1997; Bian et al, 2000; Choi et al, 2000; Wijnhoven et al, 2000b). Here, APC is linked to gastroesophageal junction adenocarcinoma.