This is in accordance with studies that demonstrated biallelic inactivation of the AXIN1 gene in several tumour types (Satoh et al, 2000b; Laurent-Puig et al, 2001; Taniguchi et al, 2002; Yokota et al, 2002), although heterozygous AXIN1 gene inactivation has also been described (Dahmen et al, 2001b; Webster et al, 2000a). Here, AXIN1 is linked to neoplasm.