Previously, we reported constitutive NF-κB activation in the ERα-negative breast cancer cell line MDA-MB-231, which correlated with increased expression of several NF-κB-inducible genes including IL-6, Mn-SOD, cIAP-2 and TRAF-1 (Patel et al, 2000). This evidence concerns the gene ESR1 and breast carcinoma.