As PLK3 is also expressed in irreversible postmitotic cells like neuronal ganglion cells (data not shown), it is intriguing to speculate on the basis of data obtained in neuronal cells (Kauselmann et al, 1999) and in macrophages (Holtrich et al, 2000) that the proposed interaction of PLK3 with CIB might play a role in determining the adhesiveness of tumour cells, albeit functional evidence for such a role of PLK3 in tumours is lacking. This evidence concerns the gene PLK3 and neoplasm.