Surprisingly, from the analysis of CD8+ T-cells specific for non-HIV viral antigens in donors with suitable human leukocyte antigen (HLA) type (HLA-A*0201 for CMV, EBV, and influenza A virus; HLA-B*0701 for CMV; and HLA-B*0801 for EBV), both CMV- and EBV-specific CD8+ T-cells displayed significant levels of activation exclusively during acute HIV infection, compared to chronic infection (p < 0.002) (Figure 1D; see Table 1). This evidence concerns the gene CD8A and HIV infectious disease.