The differentiation phenotype of non-HIV-specific CD8+ T-cells could also vary from acute to postacute HIV infection stages in relation to activation: while the differentiation phenotype of influenza A virus-specific cells remained unchanged, CMV- and (although less frequently) EBV-specific CD8+ T-cells became further differentiated (Figure 3D; Figure 4B). The gene discussed is CD8A; the disease is HIV infectious disease.