In patients with metachronous colorectal carcinoma serum concentration of TGF-alpha was significantly higher 30 min and 7 days after PH than before operation (31.5 – 6.0 and 29.5 – 6.2 vs 20.1 – 6.5 pg/mL, p &lt; 0.05, respectively) however, there was no difference in serum level of TGF-alpha between malignant and benign liver tumor patients after PH (Fig. 4). This evidence concerns the gene TGFA and colorectal carcinoma.