No difference in the LI was detected between liver tissue taken from malignant and benign liver tumor patients 30 min after hepatectomy, however the PCNA LI for colorectal liver metastatic patients was significantly higher than for benign tumor group 7 days after liver resection (42.4 – 10.2 vs 23.0 – 7.4, p &lt; .05). Here, PCNA is linked to benign neoplasm.