In conclusion, the loss of hormone dependence in this prostate cancer xenograft model is marked by irreversible histological alterations, mucinous or neuroendocrine, that are associated with a constant increase in the expression of secretory MUC2, MUC5B and MUC6, which might participate in an unknown pathway of hormone escape in prostate cancer. The gene discussed is MUC5B; the disease is prostate cancer.