In conclusion, the loss of hormone dependence in this prostate cancer xenograft model is marked by irreversible histological alterations, mucinous or neuroendocrine, that are associated with a constant increase in the expression of secretory MUC2, MUC5B and MUC6, which might participate in an unknown pathway of hormone escape in prostate cancer. This evidence concerns the gene MUC5B and prostate carcinoma.