Among these were putative tumour suppressors including the p53 mediator paternally expressed gene-3 (PEG-3) (Relaix et al, 1998; Deng and Wu, 2000), wnt-inducible signalling protein-2 (WISP-2), a member of the connective tissue growth factor family (Pennica et al, 1998), and the Rho-associated transcriptional coactivator four-and-a-half LIM domains 2 (FHL2) (Muller et al, 2002). This evidence concerns the gene CCN2 and neoplasm.