A TGFβ2-dependent increase in MUC4 expression in pancreatic adenocarcinoma (Choudhury et al, 2000b) and elevated levels of TGFβ2 transcripts in MUC4-expressing OT tumours suggest the involvement of this cytokine in MUC4 regulation by autocrine and/or paracrine manner in CD18/HPAF tumours. The gene discussed is TGFB2; the disease is pancreatic adenocarcinoma.