However, at least three genes induced in the fibroblast serum response, PLAUR, LOXL2, and MIF, have been previously shown to increase cancer invasiveness or angiogenesis in animal xenograft models; each of these three genes has also been shown to play an important role in wound healing (Akiri et al. 2003; Nishihira et al. 2003; Sidenius and Blasi 2003). This evidence concerns the gene MIF and cancer.