We investigated the possible association between the SLIT2 promoter region CpG island methylation and SLIT2 transcript expression in a panel of RCC cell lines (SKRC 18, SKRC 39, SKRC 45, SKRC 47, SKRC 54, KTCL 26,UMRC-2 and 786-0). This evidence concerns the gene SLIT2 and renal cell carcinoma.