RASSF1 and cancer: This paradigm is exemplified by the RASSF1A 3p21.3 TSG, which is methylated in a wide range of human cancers (Dammann et al, 2000; Agathanggelou et al, 2001; Astuti et al, 2001; Burbee et al, 2001; Dreijerink et al, 2001; Morrissey et al, 2001).