Most of the linkage evidence in support of the PCAP locus at 1q42–43 is derived from families from France and England (Berthon et al, 1998; Cancel-Tassin et al, 2001); many of the published prostate cancer linkage studies in other populations have not provided significant support for this putative locus (for example, Berry et al, 2000a; Xu et al, 2001). The gene discussed is CSAD; the disease is prostate carcinoma.