CDKN2A and melanoma: The frequency of INK4a-ARF mutations in melanoma probands increases with (i) the number of affected relatives, (ii) the presence of multiple melanomas in the same patient, (Soufir et al, 1998a; Holland et al, 1999) and (iii) a history of pancreatic cancer cases in the family (Goldstein et al, 1995).