Aging has been associated with depressed in situ repair of UV-specific DNA lesions in the skin of subjects carrying the XPD variants 312Asn and 751Gln (Hemminki et al, 2001), who may therefore be at higher risk for cancer at an older age (Dybdahl et al, 1999; Sturgis et al, 2000). This evidence concerns the gene ERCC2 and cancer.