Membrane localisation of IQGAP1 was previously found to be inversely correlated with the degree of differentiation of gastric carcinoma cells (Takemoto et al, 2001) and was observed in human colorectal carcinoma cells, especially at the invasion front (Nabeshima et al, 2002), as well as in human colon carcinoma cells following treatment with heptocyte growth factor (HGF) (Shimao et al, 2002). This evidence concerns the gene HGF and colorectal carcinoma.