ERBB2 and pachyonychia congenita: The published incidence of HER-2/neu overexpression is typically in the range of 25–40% and 60–80%, respectively, in localised PC (Sadasivan et al, 1993; Ross et al, 1997; Fossa et al, 2002) and in metastatic PC (Osman et al, 2001; Morris et al, 2002).