In addition to this, it was recently shown that the EGF-induced cell migration of EGFR/c-erbB-2-positive breast cancer cells, but not of solely EGFR-positive breast cancer cells, could be blocked with moderate concentrations of the PLC-γ1 inhibitor U73122 (Dittmar et al, 2002). Here, PLCG1 is linked to breast carcinoma.