A decisive step in the initiation of migration of epidermal growth factor receptor (EGFR)/c-erbB-2-positive breast cancer cells has been attributed to the specific phosphorylation of tyrosine residue 1248 of c-erbB-2 via EGFR, thereby modulating the time course of the adaptor protein phospholipase C-γ1 (PLC-γ1) (Dittmar et al, 2002). Here, PLCG1 is linked to breast cancer.