EGF and breast carcinoma: In addition to this, it was recently demonstrated by Dittmar et al (2002) that the induction and maintenance of the EGF-mediated cell migration of EGFR/c-erbB-2-positive breast cancer cells is driven by the c-erbB-2-dependent EGFR/c-erbB-2 heterodimer signalling, thereby modulating the PLC-γ1 kinetics.