DEFA5 and adenoma: In comparison, group 2, a mixture of larger low- and high-grade adenomas, as well as one adenocarcinoma, was characterised by the overexpression of two intestine-specific genes, CDH17 and DEFA5. LI-Cadherin is usually expressed in normal intestinal mucosa and ectopically in well-differentiated gastric adenocarcinomas (Grotzinger et al, 2001).