In some studies, the expression of p53 was associated with a higher frequency of serosal, vascular, and lymphatic invasion, increased lymph node metastases and, consequently, a more advanced tumour stage (Kakeji et al, 1993; Kim et al, 1997; Monig et al, 1997; Maehara et al, 1999). This evidence concerns the gene TP53 and neoplasm.