In this study, we investigated the immunohistochemical expression of Bcl-2, caspase-3 and p53 protein directly involved in the regulation of apoptosis, Ki67 marker for proliferation, detected apoptotic cells by TUNEL staining, and evaluated the relation of these factors to clinicopathological characteristics and prognosis in patients with RCC. The gene discussed is BCL2; the disease is renal cell carcinoma.