BCL2 and renal cell carcinoma: However, in RCC, several studies have shown that Bcl-2 positivity was not associated with prognosis (Lipponen et al, 1995; Vasavada et al, 1998; Huang et al, 1999; Sejima and Miyagawa, 1999; Zhang and Takenaka, 2000; Uchida et al, 2002).