FGFR3 and plasma cell myeloma: The role of FGFR4 in carcinogenesis is still under investigation, notably the relation between genotype and phenotype, but also its involvement in cancer progression via paracrine/autocrine modulation of FGFR4 ligands and FGFR4 and its possible implication in an oncogenic multistep process, as described for FGFR3 in multiple myeloma (Chesi et al, 2001).