The role of FGFR4 in carcinogenesis is still under investigation, notably the relation between genotype and phenotype, but also its involvement in cancer progression via paracrine/autocrine modulation of FGFR4 ligands and FGFR4 and its possible implication in an oncogenic multistep process, as described for FGFR3 in multiple myeloma (Chesi et al, 2001). This evidence concerns the gene FGFR3 and cancer.