These were: CPS1, LCP1, the metabolic enzyme 3-hydroxyisobutyryl coenzyme A hydrolase (HIBCH), copine III, which may be involved in membrane trafficking (Creutz et al, 1998) and ubiquitin C-terminal hydrolase isozyme L1 (UCHL1), a deubiquitinating enzyme whose overexpression has been associated with progression of non-small-cell lung cancers (Hibi et al, 1999) and colon cancer invasiveness (Yamazaki et al, 2002). Here, HIBCH is linked to malignant colon neoplasm.