INS and diabetes mellitus: In the peripheral nervous systemIGF-I, insulin, and C-peptide particularly in type 1 diabetesparticipate in the development of axonal degenerativechanges and contributes to impaired regenerative capacities.These abnormalities of the IGF system appear to beless pronounced in type 2 diabetes, which may in part accountfor the relatively milder neurological complicationsin this type of diabetes.