Upon switching on the expression of TRAIL, these manipulated cells induced strong paracrine apoptosis in human Burkitt lymphoma (BJAB) cells in vitro and in vivo. The antitumoral effect of TRAIL was specifically mediated by membrane-bound TRAIL via the death receptor pathway, and enhanced the therapeutic potential of cytotoxic drugs. The gene discussed is TNFSF10; the disease is Burkitt lymphoma.