In approximately 40% of sporadic clear cell RCC, the inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene located on chromosome 3p25 has been observed and seems to play a major role for the development of this tumour type (Foster et al, 1994, Gnarra et al, 1994, Brauch et al, 2000, Mandriota et al, 2002). This evidence concerns the gene ENSG00000279284 and neoplasm.