In approximately 40% of sporadic clear cell RCC, the inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene located on chromosome 3p25 has been observed and seems to play a major role for the development of this tumour type (Foster et al, 1994, Gnarra et al, 1994, Brauch et al, 2000, Mandriota et al, 2002). Here, ENSG00000280371 is linked to neoplasm.