As reported (Bouterfa et al, 1999; Oz et al, 2000; Mahesparan et al, 2003), FN, laminin, collagen-IV and -I, decorin, tenascin and vitronectin are ECM proteins produced and secreted by cells of malignant tumours of glial origin in vitro and in vivo. The gene discussed is FN1; the disease is neoplasm.