In particular, MMP-7 is characterized by (1) broad and strong proteolytic activity against a variety of extracellular matrix substrates such as collagens, proteoglycans, laminin, fibronectin, and casein, (2) lack of a c-terminal domain, so it is not regulated easily by tissue inhibitor of metalloproteinases (TIMP), and (3) production by tumour cells themselves (Miyazaki et al, 1990; Matrisian, 1992; Baragi et al, 1994; Adachi et al, 1998). Here, MMP7 is linked to neoplasm.