Furthermore, AKT activation correlated with the histologic grade, which remains one of the most significant prognostic variables in this cancer, surpassing tumour size or nodal status for predicting survival (Takahashi et al, 1997; Eskelinen and Haglund, 1999; Luttges et al, 2000; Kedra et al, 2001). This evidence concerns the gene AKT1 and neoplasm.