Inhibition of both HER-2/neu and AKT has been shown to increase the apoptotic sensitivity of pancreatic cancer in vitro and in vivo (Ng et al, 2000, 2001; Buchler et al, 2001; Bondar et al, 2002; Fahy et al, 2003). This evidence concerns the gene AKT1 and familial pancreatic carcinoma.