Considering that the overexpression of the AP-1 (Tessari et al, 1999; Meggiato et al, 2003), VEGF (Seo et al, 2000), MMP-1 (Ito et al, 1999), and MMP-3 (Bramhall et al, 1996) has been demonstrated in human pancreatic cancer, together with our results, the interactions among these molecules may play an important role in pancreatic neoplastic transformation in vivo, Further studies, including the determination of expression levels of these molecules in tissue samples, have yet to be carried out to further clarify this issue. This evidence concerns the gene MMP1 and familial pancreatic carcinoma.