Various methods have recently tried to concentrate TNFα into tumour such as Cu2+-dextran (Tabata et al, 1999), TNFα-biotin conjugates (Moro et al, 1997; Gasparri et al, 1999), or liposomal encapsulated-TNFα (Kim et al, 2001) which are less specific targeting than our BAb and were not tested with concomitant radiotherapy. Here, TNF is linked to neoplasm.