In addition to the loss of MBD2 and MeCP2 in human cancers (Müller-Tidow et al, 2001), it has been shown in colon cancer cell lines that MBD2 is associated with methylated promoters of silent p14/p16 gene, and this methylation-dependent association seems to be responsible for their silencing (Magdinier and Wolffe, 2001). Here, MBD2 is linked to colonic neoplasm.