An important role in uveal melanoma development is now suggested for Laminin Receptor 1 (LAMR1), Endothelin 2 (ET2), Von Hippel Lindau Binding Protein 1 (VBP1) and Cullin 2 (CUL2) genes, since their expression levels discriminate between two classes of uveal melanoma. This evidence concerns the gene RPSA and uveal melanoma.