Our aims were: 1) to compare histological type and grading of endometrial carcinoma in curettage and hysterectomy samples; 2) to assess the expression of p53, estrogen and progesterone receptors in curettage specimens; and 3) to correlate these data with morphology and staging of the disease in the hysterectomy specimens. This evidence concerns the gene TP53 and endometrial carcinoma.