The classical prognostic factors are histological type and grading, depth of myometrial invasion and extent in the cervix.5-7 It has been suggested that the expression of p53 protein, as well as estrogen and progesterone receptors, may have prognostic significance.8,9 p53 protein is expressed more in aggressive tumors, which suggests that mutation of the gene renders the neoplastic cells resistant to apoptosis.10 On the other hand, estrogen and progesterone receptors are usually associated with well-differentiated endometrial tumors.8,10-12. The gene discussed is TP53; the disease is endometrium neoplasm.