Although a subset of the 34 genes differentially expressed over four-fold in LoVo cells and c-Myc-overexpressing L2 and L3 cells is likely to play a role in their differential apoptotic response to camptothecin, elevated c-Myc levels have been shown to affect other phenotypic characteristics of colon cancer cells, including cell cycle progression and basic metabolism (Tikhonenko et al, 1996; Dang, 1999; Menssen and Hermeking, 2002). Here, MYC is linked to malignant colon neoplasm.