Of the 34 genes that varied in expression over four-fold in parental LoVo cells and c-Myc-overexpressing L2 and L3 cells, 10 showed a significant correlation (R>0.39; P<0.037) between expression levels and response to camptothecin in each of the 30 colorectal cancer cell lines in our panel (Table 1). This evidence concerns the gene MYC and colorectal cancer.