P53 protein accumulation has been detected by immunohistochemistry in 7% of LGD, 30–60% of HGD and 45–85% of adenocarcinoma (with most reports closer to the 80% level), but not in metaplastic Barrett's epithelia (Moskaluk et al, 1996; Coggi et al, 1997; Rioux-Leclercq et al, 1999). Here, TP53 is linked to adenocarcinoma.