Sawada and Endo et al discovered that particular cytostatics, such as taxanes, mitomycin C (MMC) and cyclophosphamide (CPA), up-regulated TP expression preferentially in the tumour tissue when therapeutic dose levels of these drugs were administered, even after oral CPA administration, whereas TP was not affected in normal tissues including the small intestine and liver. Here, TYMP is linked to neoplasm.