Activation of human c-myc has been shown to be a common event in intermediate- and high-grade NHL (Gaidano et al, 1993) and so the recurrent gain of CFA 13 observed in this study suggests that it is crucial to examine the potential involvement of c-MYC and c-KIT in canine tumour development. The gene discussed is KIT; the disease is non-Hodgkin lymphoma.