Monni et al (1996, 1997) demonstrated, using CGH analysis, that this human chromosome region is commonly amplified in several NHL subtypes and can be directly correlated with aberrant overexpression of a specific oncogene, BCL2 (HSA 18q21.3), contained within the amplified chromosome region (HSA 18q21–q23). Gain of material from CFA 35 in two cases may correspond to the common amplification of HSA 6p in human lymphoma (e.g Monni et al, 1996) as these sites share an evolutionary origin (Breen et al, 1999a; Yang et al, 1999). Here, BCL2 is linked to non-Hodgkin lymphoma.