Single nucleotide polymorphisms in the MGMT gene can have effects on the MGMT activity (Hazra et al, 1997) or on sensitivity to the MGMT inhibitor O6-benzylguanine (O6-BG) (Edara et al, 1996; Pegg et al, 1998) and might therefore have an effect on clinical response to DTIC-based chemotherapy in melanoma. Here, MGMT is linked to melanoma.