SPARC and Barrett esophagus: Analysed according to histopathologic group, the median SPARC mRNA expression was lowest in normal squamous oesophagus tissues (median 0.95, range 0.14–16.50), intermediate in BE (median 3.89, range 0.09–53.62), and highest in EA of the oesophagus (median 13.79, range 1.81–105.22; P<0.001, Kruskal–Wallis test).