SPARC and Familial prostate cancer: The overexpression of SPARC has been detected in melanoma (Ledda et al, 1997a), colorectal cancer (Porte et al, 1995), breast cancer (Bellahcene and Castronovo, 1995), hepatocellular carcinoma (Le Bail et al, 1999), invasive meningiomas (Rempel et al, 1999), and prostate cancer (Thomas et al, 2000).