IFNG and breast cancer: As shown in Figure 5B, both the ratio between IL-2+ and IL-4+ lymphocytes and the ratio between IFN-γ + and IL-4+ lymphocytes, in PMA-stimulated cultures, were significantly lower in breast cancer than in control subjects (IL-2/IL-4: 10.06 ± 1.61 vs 25.01 ± 5.97%, P=0.049; IFN-γ/IL-4: 10.43 ± 1.47 vs 21.07 ± 4.18%, P=0.048).