Although the numbers of tumours analysed were limited, the observations that the tumours of grade 4 seemed to express less LRIG1 than tumours of lower grades and that a small survival benefit for patients with tumours with high expression of LRIG1 were indicated; this might lend further support to the fact that LRIG1 participates in the oncogenesis of RCC. Here, LRIG1 is linked to renal cell carcinoma.