The phenotype observed in dwarfism suggests that the dysregulation of FGFR3 could impair cell growth and differentiation (Su et al, 1997; Legeai-Mallet et al, 1998; Sahni et al, 1999), knockout mouse studies confirming an inhibitory role for FGFR3 in bone growth (Colvin et al, 1996; Deng et al, 1996). The gene discussed is FGFR3; the disease is Severe short stature.