However, significantly elevated levels of CD40, CD80, CD86, and HLA-DR on CML-DC transduced by CD40-targeted Ad-GM-CSF could be maintained until days 7–14 as compared to CML-DC transduced by untargeted Ad-GM-CSF or CD40-retargeted Ad-CEA (Figure 2D). Here, CD40 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.