TNF and melanoma: Although our current study reports observations made on a single cell line, our data are in agreement with previous reports from the literature on the effects of TNF-α on the functional biology of different human malignancies including melanoma (Dekker et al, 1994; Balkwill, 2002) and extend ongoing work from our group on the effects of proinflammatory cytokines on human melanoma by examining the role of proteolytic enzymes in the invasion and migration of these cells.