Further, purified preparations of HSC70, gp96, HSP70, and calreticulin isolated from cancer cells have been shown to elicit cancer-specific immunity against a wide range of cancers in animal models (Tamura et al, 1997; Srivastava et al, 1998; Dressel et al, 1999; Robert et al, 2001; Udono et al, 2001). This evidence concerns the gene HSP90B1 and cancer.