LNCaP prostate carcinoma cells, three pancreatic cells (Miapaca-2, Capan-2 and CF-PAC-1) and three colon cancer cells (HCT116, COLO 205 and COLO 320) showed a significant increase in erbB-2 mRNA levels without gene amplification. The gene discussed is ERBB2; the disease is colonic neoplasm.